We have discovered that having a Windows programming running in macOS using Wine (see https://www.winehq.org ) is stopping the touch device from working on our test system using UPDD V6.
After further investigation we found the following steps prevent Wine from interfering with your touch device:
1. Run winecfg
2. Go to the Libraries tab
3. Type winebus.sys in the "New override for library" box
4. Click Add
5. Ignore the warning about this not being recommended and click Yes to dismiss it
6. Select winebus.sys from the "Existing overrides" box and click Edit
7. Select Disable and click OK on the popup dialog
8. Repeat steps 3-7, except this time replace winebus.sys with wineusb.sys
9. Click OK to save the changes and close winecfg
Note that this will prevent other HID devices from working other than the mouse and keyboard, as well as direct access to USB devices.
Hopefully Wine users will know what the above means without extra context.